RESEARCH PROJECTS

The main goal is to understand and elucidate the mechanisms of treatment response 
propensity in patients suffering from chronic low back pain.

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PROJECT 1- PATIENT’S PREDISPOSITION

The first project of this research program is to identify brain, psychometric and genetic characteristics of CLBP 
patients that are predictive of pain treatment responses. This cross-sectional goal will use multimodal data to 
build prediction models based on parameters that are present in patients before the initiation of the treatment 
that will predict future outcomes.

PROJECT 2- PATIENT’S ADAPTATION

The second project of this research program is to identify which CLBP patients’ brain, psychometric and 
genetic characteristics change when a treatment is inducing pain relief and how do they change. This 
longitudinal goal will use multimodal data acquired at multiple time points to identify those adaptive 
characteristics of treatment response.

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PROJECT 3- PRECLINICAL VALIDATION

The third project of this research program is to perform cross-validation in preclinical models. Based on existing 
literature and the results obtained from the first two projects, this reverse translational animal goal will also 
use multimodal data acquired at multiple time points to find prediction models and treatment induced changes 
comparable to what was found in humans to ultimately optimize future human studies. (rat image by Renaud Poupart)