The main goal is to understand and elucidate the mechanisms of treatment response
propensity in patients suffering from chronic low back pain.
PROJECT 1- PATIENT’S PREDISPOSITION
The first project of this research program is to identify brain, psychometric and genetic characteristics of CLBP
patients that are predictive of pain treatment responses. This cross-sectional goal will use multimodal data to
build prediction models based on parameters that are present in patients before the initiation of the treatment
that will predict future outcomes.
PROJECT 2- PATIENT’S ADAPTATION
The second project of this research program is to identify which CLBP patients’ brain, psychometric and
genetic characteristics change when a treatment is inducing pain relief and how do they change. This
longitudinal goal will use multimodal data acquired at multiple time points to identify those adaptive
characteristics of treatment response.
PROJECT 3- PRECLINICAL VALIDATION
The third project of this research program is to perform cross-validation in preclinical models. Based on existing
literature and the results obtained from the first two projects, this reverse translational animal goal will also
use multimodal data acquired at multiple time points to find prediction models and treatment induced changes
comparable to what was found in humans to ultimately optimize future human studies. (rat image by Renaud Poupart)